NXC828

NXC828 is a novel HIF-1α inhibitor being developed for the treatment of wet age-related macular degeneration (wet-AMD) as an eye drop formulation. Current standard treatments of wet-AMD are anti-VEGF intravitreal injections which entail a variety of issues such as injection-associated side effects, fear of injection and high medical costs. An eye drop formulation may be the solution to alleviating these unmet medical needs by allowing patients to self-administer the medication at anytime and anywhere while avoiding injection-associated side effects.

Indication Wet-AMD
Route of Administration Eye drop
Development Status Pre-clinical
Mechanism of Action HIF-1α inhibitor
Highlight
  • Eye drop formulation for the treatment of wet-AMD
  • Therapeutic concentration observed in the retina of rabbit
  • Non-inferior efficacy to anti-VEGF intravitreal injection shown in rat and rabbit CNV studies
  • Significant efficacy observed in nonhuman primate CNV study